Ralph Said:

why should that diabetes mellitus is interested in our case study?

We Answered:

I've often pondered this very dilemma myself. In the case of most patients, they often look at case studies as a nuisance. Others look at them as a means for pharmaceutical companies to get even richer. Personally, I think the answers lie somewhere between the two extremes.

Maurice Said:

chemistry case study topics; diabetes?

We Answered:

Type 2 diabetes is a good topic for discussion. The flaws are many and varied. There is an approximately 50% loss of beta (insulin producing) cells of the pancreas by the time of diagnosis and there is increased beta cell apoptosis (cell death). Pro-insulin which is stored in the pancreas may be stored or released incorrectly. The pancreas does not always cleave the C-Peptide off of pro-insulin which means that the insulin will not work as well. Alpha cells in the pancreas do not secrete glucagon correctly and excessive glucagon causes the liver to release glucose inappropriately. There is cellular resistance to the effects of insulin most especially myocytes (muscle cells) which are the primary utilizer of glucose. The brain however is an obligate glucose consumer and nerve cells undergo faulty glucose metabolism via sorbital reductase. This creates an osmotic gradient and water enters susceptible nerve cells resulting in diabetic neuropathy. There is also the question of an unknown 'second messenger' that most likely causes inappropriate metabolism of glucose in adipocytes (fat cells) and myocytes. The incretin mimetics made by the gastrointestinal system are degraded too rapidly. The stomach empties too quickly making the degradation of incretin mimetics of greater consequence. The brain does not retain the sense of satiety meaning the sense that we are full and should stop eating. Circulating insulin and glucose affect the rheology of blood flow and indeed the cardiovascular complications seen in diabetes are profound. The genetics of type 2 diabetes are poly-genetic with incomplete penetrance meaning that multiple as yet unidentified genes are involved and that these genes may be 'on' or 'off'. The glycated hemoglobin A1C provides the 90 day mean (average) glucose. This test is biochemically of interest as it is 'glycated' not 'glycosylated' as most laboratories allege. See M. Roth's poetic description of glycation 'Glycated Hemoglobin' in Clinical Chemistry 1983. Hopefully this will offer some food for thought. If I may be of further assistance please let me know. I wish you the very best of health and in all things may God bless.

Claudia Said:

Does anyone think that i am on the right track with this case study?

We Answered:

Administering insulin via iv and putting in a catheter seems like over kill on a patient with a BG of 288 without knowing when the last meal was and was the level going up or down. A simple injection of a fast acting insulin may be in order but without ketones in the urine I would be looking at heart/lung issues and monitor the diabetes issues. She has diabetes, she does not have risk factors for developing type 2 diabetes, she IS diabetic.

Ruth Said:

Can someone help me find a good website for my case study?

We Answered:

http://www.bookrags.com/research/glucose…


http://www.ajronline.org/cgi/content/abs…

http://www.rnceus.com/ld/ldanat.html

http://en.wikipedia.org/wiki/Insulin

i hope this helps in you
goodluck

Helen Said:

Discuss the patient’s diagnosis of Type 1 Diabetes Mellitus. How would you diagnosis a child with this?

We Answered:

WWW.diabetes.org is the official website for the American Diabetes Assoc.

Marie Said:

what is the connection of Diabetes mellitus in keratoplasty?

We Answered:

Diabetes can effect the eyes and can lead to many eye complications
for more on eye diseases due to diabetes vsit mt free website http://www.reddiabetes.com

Automated lamellar keratoplasty eye surgery, or ALK, is a surgical procedure used to correct vision in people with severe nearsightedness and mild degrees of farsightedness.

What Happens During Keratoplasty Eye Surgery?
Keratoplasty eye surgery, performed under local anesthesia, usually takes less than an hour to complete. A cutting device is used to make a small incomplete flap across the cornea. While still attached at one side, the corneal flap is folded back to reveal the layer of tissue below. Another, very precise cut is made on the sub layer of tissue based on the person's glasses' prescription. After this cut, the corneal flap is placed back over the eye where it reattaches.

What Are the Advantages of Keratoplasty Eye Surgery?
Compared to other vision repair surgeries:

The healing process for keratoplasty eye surgery is relatively quick
It takes less time for stable vision to return
Recovery period is more comfortable

What Are the Disadvantages of Keratoplasty Eye Surgery?
While keratoplasty eye surgery is a safe and effective surgery, it does have its disadvantages. They include:

For people with mild to moderate nearsightedness, keratoplasty eye surgery is not as accurate as other eye procedures, meaning that its outcome is more difficult to predict.
Keratoplasty eye surgery slightly increases a person's risk of developing an irregular astigmatism.

What Are the Potential Side Effects of Keratoplasty Eye Surgery?
Aside from the above-mentioned disadvantages, side effects, though rare, do occur. These may include:

Glare
Inability to wear contacts, sometimes permanently
Infection
Corneal scarring

How Should I Prepare for Keratoplasty Eye Surgery?
Before your keratoplasty eye surgery you will have met with a coordinator who will discuss with you what you should expect during and after the surgery. During this session your medical history will be evaluated and your eyes will be tested. Likely tests will include measuring corneal thickness, refraction, and pupil dilation. Once you have gone through your evaluation, you will meet the surgeon, who will answer any further questions you may have. Afterwards, you can schedule an appointment for the keratoplasty eye surgery.

If you wear rigid gas permeable contact lenses, you should not wear them during the three weeks before keratoplasty eye surgery. Other types of contact lenses shouldn't be worn for at least three days prior to keratoplasty eye surgery. Be sure to bring your glasses to the surgery so your prescription can be reviewed.

On the day of your keratoplasty eye surgery, eat a light meal before going to the doctor and take all of your prescribed medications. Do not wear eye makeup or have any bulky accessories in your hair that will interfere with positioning your head under the laser. If you do not feel well that morning, call the doctor's office to determine whether the keratoplasty eye surgery needs to be postponed.

What Should I Expect After Keratoplasty Eye Surgery?
The healing time from keratoplasty eye surgery is very rapid. It usually takes only about 24 hours to mend. But it may take a few weeks for your vision to finally stabilize.

Your doctor will give you eye drops to control inflammation, discomfort, and prevent infection.

Stella Said:

CASE STUDY I am confused about?

We Answered:

1. progeria is a disorder of rapid and advanced aging. only 130 documented cases on 150 years or so.
2. The genetic mutation happens in the Lamin A protein
3. There is currently no treatment.
4. Prognosis is a shortened lifespan usually into the teens, perhaps the 30's. usually ding of stroke heart attack.
5. Lamin A is a structural fiberous protein in the nucleus. It also provides transcription regulation.